21900-35-6

Upstream product

• 586-76-5 4-Bromobenzoic acid 
• 619-03-4 3,4-dibromobenzoic acid 

Downstream Products

• 145028-54-2 3,4-Dibromo-N-[3-(2,3,5,6-tetrahydro-imidazo[2,1-b]thiazol-6-yl)-phenyl]-benzamide 
• 119878-31-8 3,4-Dibromo-N-methyl-N-((5S,6R)-1-methyl-1-aza-spiro[4.5]dec-6-yl)-benzamide 
• 74418-41-0 tert-butylamide of 3,4-dibromobenzoic acid 
• 74418-42-1 diethylamide of 3,4-dibromobenzoic acid 
• 74418-51-2 3,4-dibromobenzanilide 
• 96238-00-5 1-(3,4-dibromobenzoyl)-2-(p-nitrobenzoyl)hydrazine 
• 188024-78-4 (3,4-Dibromo-phenyl)-(3-hydroxy-3-phenyl-piperidin-1-yl)-methanone 
• 74418-43-2 dibutylamide of 3,4-dibromobenzoic acid 

Relevant academic research and scientific papers

Substitution Reactions of Phenylated Aza-Heterocycles. Part 2. Bromination of Some 2,5-Diaryl-1,3,4-oxadiazoles

Electrophilic bromination of the title compounds may be achieved using either bromine in oleum, or bromine and potassium bromate in a sulphuric-acetic acid mixture.Under the milder reaction conditions provided by the latter, 2-(p-nitrophenyl)-5-phenyl-1,3,4-oxadiazole (2), the model compound used in this study, is mono- and di-brominated in the phenyl ring.In the first bromination step, all three monobromo-isomers are produced in appreciable amount.The orientation of the second bromination is controlled entirely by the first bromine and not by the oxadiazole substituent: this is confirmed by a separate study of the bromination of the three monobromo-compounds (3a-3c).