219121-25-2Relevant academic research and scientific papers
Inhibitors of MMP-1: An examination of P1' Cα gem-disubstitution in the N-carboxylalkylamine and glutaramide carboxylate series
Robinson, Ralph P.,Cronin, Brian J.,Donahue, Kathleen M.,Jones, Brian P.,Lopresti-Morrow, Lori L.,Mitchell, Peter G.,Rizzi, James P.,Reeves, Lisa M.,Yocum, Sue A.
, p. 1725 - 1730 (2007/10/03)
Modification of the N-carboxyalkylamine 3 by independent replacement of the P1' NH group for CH2 and introduction of P1' gem-cyclohexyl substitution affords compounds 5 and 6a which retain appreciable activity against MMP-1 (IC50s = 0.023 μM and 0.09 μM, respectively). The glutaramide 7a which incorporates both these structural changes also retains potent activity (IC50 = 0.038 μM).
