219136-33-1

Upstream product

• 169124-54-3 (S)-4-tert-butyldimethylsilyloxy-2,6,6-trimethyl-2-cyclohexenone 

Downstream Products

• 219136-39-7 (1S,2S,3S)-3-tert-Butoxy-2-[(R)-2-((S)-1-hydroxy-2,6,6-trimethyl-4-oxo-cyclohex-2-enyl)-2-methoxymethoxy-ethyl]-2-methyl-6-methylene-cyclohexanecarbaldehyde 
• 872315-06-5 (4R,5S,8S)-4-((1S,2S,6S)-6-tert-Butoxy-2-hydroxymethyl-1-methyl-3-methylene-cyclohexylmethyl)-6,10,10-trimethyl-1,3-dioxa-spiro[4.5]dec-6-en-8-ol 
• 872315-05-4 (4R,5S,8S)-4-[(1S,2S,6S)-6-tert-Butoxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-1-methyl-3-methylene-cyclohexylmethyl]-8-(tert-butyl-dimethyl-silanyloxy)-6,10,10-trimethyl-1,3-dioxa-spiro[4.5]dec-6-ene 
• 219136-72-8 (1S,4S)-1-[(R)-2-((1S,2S,6S)-6-tert-Butoxy-2-hydroxymethyl-1-methyl-3-methylene-cyclohexyl)-1-methoxymethoxy-ethyl]-2,6,6-trimethyl-cyclohex-2-ene-1,4-diol 

Relevant academic research and scientific papers

Matched and mismatched pairings in B-secotaxane construction: A structure elucidation study

The synthesis of the basic B-seco taxoid skeleton was achieved through a C10-C11 coupling of the A-ring segment (14S)-1 with the C-ring segments (10S) and (10R)-α-alkoxyorganolithium reagents, prepared in situ from 2 and 6 through nBuLi mediated transmeta

An expedient synthesis of a conveniently functionalized optically homogeneous taxoid ABC ring system

We present a four-step A+C route to an optically pure taxoid ABC framework 3a containing suitable functionalities for further elaboration.