21919-05-1 Usage
Uses
Used in Anticancer Applications:
5-Aziridino-2,4-dinitrobenzamide is used as an anticancer prodrug in gene therapy research for its ability to be activated by NAD(P)H Quinone Oxidoreductase 2. It is particularly effective in forming DNA-DNA interstrand crosslinks, which can lead to the disruption of cancer cell replication and ultimately, cell death.
Used in Gene Therapy Research:
In the field of gene therapy, 5-Aziridino-2,4-dinitrobenzamide is used as a prodrug that can be selectively activated by the NQO1 enzyme, which is overexpressed in certain cancer cells. This selective activation allows for a targeted approach to cancer treatment, minimizing damage to healthy cells and reducing side effects.
Used in Drug Development:
5-Aziridino-2,4-dinitrobenzamide serves as a key compound in the development of novel anticancer drugs. Its unique mechanism of action and the ability to be activated by a specific enzyme make it an attractive candidate for the creation of targeted therapies that can be tailored to individual patients' needs and the specific characteristics of their cancer.
Used in Combination Therapies:
5-Aziridino-2,4-dinitrobenzamide is also used in combination with other anticancer agents to enhance the overall effectiveness of treatment. Its activation by NQO1 allows for synergistic effects when used alongside other chemotherapeutic drugs, potentially improving patient outcomes and overcoming resistance to traditional chemotherapy.
Used in Preclinical and Clinical Studies:
As a prodrug with potential anticancer properties, 5-Aziridino-2,4-dinitrobenzamide is utilized in preclinical and clinical studies to evaluate its safety, efficacy, and optimal dosing strategies. These studies are crucial for advancing the understanding of its role in cancer treatment and for determining its potential as a component of future therapeutic regimens.
Biochem/physiol Actions
CB 1954 is an anticancer prodrug used in gene therapy research; activated by NAD(P)H quinone oxidoreductase?2.
Check Digit Verification of cas no
The CAS Registry Mumber 21919-05-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,9,1 and 9 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 21919-05:
(7*2)+(6*1)+(5*9)+(4*1)+(3*9)+(2*0)+(1*5)=101
101 % 10 = 1
So 21919-05-1 is a valid CAS Registry Number.
InChI:InChI=1/C9H8N4O5/c10-9(14)5-3-7(11-1-2-11)8(13(17)18)4-6(5)12(15)16/h3-4H,1-2H2,(H2,10,14)
