21925-25-7Relevant academic research and scientific papers
Design, synthesis, and pharmacological effects of structurally simple ligands for MT1 and MT2 melatonin receptors
Carocci, Alessia,Catalano, Alessia,Lovece, Angelo,Lentini, Giovanni,Duranti, Andrea,Lucini, Valeria,Pannacci, Marilou,Scaglione, Francesco,Franchini, Carlo
experimental part, p. 6496 - 6511 (2010/10/02)
A series of phenoxyalkyl and phenylthioalkyl amides were prepared as melatoninergic ligands. Modulation of affinity of the newly synthesized compound by applying SARs around the terminal amide moiety, the alkyl chain, and the methoxy group on the aromatic ring provides compounds with nanomolar affinity for both melatonin receptor subtypes. Affinity towards MT1 and MT2 receptors were modulated also exploiting chirality. The investigation of intrinsic activity revealed that all the tested compounds behave as full or partial agonists.
Amino acid-mediated Goldberg reactions between amides and aryl iodides
Deng, Wei,Wang, Ye-Feng,Zou, Yan,Liu, Lei,Guo, Qing-Xiang
, p. 2311 - 2315 (2007/10/03)
A highly general, experimentally simple, and inexpensive catalyst system was developed for the amidation of aryl iodides by using 5mol% of CuI as catalyst, 20mol% of an amino acid as ligand, and K3PO4 as base.
Cathodic Reduction of Aliphatic Azides and of Azides, Activated by Olefinic and Carbonyl Groups
Knittel, Dierk
, p. 679 - 688 (2007/10/02)
In the majority of compounds investigated the main reduction path starting from azido compounds under parotic conditions leads to the retainment of one nitrogen in the product molecules, provided an initial phase of consumption of residual water is overcome.Good to excellent yields of N-acylated or nicely stable N,N-diacetylated aminoderivatives are obtainable.Even a secondary position of the original N3-group prevents diacetylation completely by steric reasons.Vicinal halogen cause the loss of all nitrogen atoms as does the presence of H+ in the case of azidocarbonyl compounds.Where reduction potential of the starting azide lies within the reduction range of Ac2O even high chemical yields of aminoderivatives are obtainable but with decrease of current efficiency.Reductive acetylation of benzoyl azide leads to the isolation of both rotational isomers of N-acetylbenzamide. - Keywords: Unsaturated Azides and Amines; α-Azido- and α-Aminocarbonylcompounds; Cathodic reduction
