219296-24-9 Usage
General Description
3-(Chlorodifluoroacetyl)imidazo[1,2-a]pyridine is a chemical compound with an elaborate structure, showcasing the typical aspects of organic chemistry. Based on its name, one can discern that it belongs to the class of imidazopyridines. This refers to a subclass of azapolyenes, one of the broad classes of organic compounds. They are characterised by a pyridine ring fused with an imidazole ring, which is then modified by an attachment of a chlorodifluoroacetyl component to it, thus creating our compound of interest. There isn't much available literature particularly about this chemical, suggesting that it may not be widely used or explored, or that it might be a synthetic intermediate or a by-product of chemical synthesis. It would likely exhibit properties typical for its class, like aromaticity and potential biological activities.
Check Digit Verification of cas no
The CAS Registry Mumber 219296-24-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,9,2,9 and 6 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 219296-24:
(8*2)+(7*1)+(6*9)+(5*2)+(4*9)+(3*6)+(2*2)+(1*4)=149
149 % 10 = 9
So 219296-24-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H5ClF2N2O/c10-9(11,12)8(15)6-5-13-7-3-1-2-4-14(6)7/h1-5H
219296-24-9Relevant articles and documents
Reaction of α-halogen substituted β-ethoxyvinyl trifluoromethyl ketones with 2-aminopyridine: New route to trifluoroacetyl-containing heterocycles
Kacharova, Liliya M,Gerus, Igor I,Kacharov, Alexey D
, p. 193 - 197 (2007/10/03)
The reaction of α-halosubstituted β-ethoxyvinyl trifluomethyl ketones with 2-aminopyridine gives 3-trifluoroacetyl imidazo [1,2-a]pyridine and 3-halo-1,1,1,-trifluoro-4-(2-pyridinylamino)-3-buten-2-ones. The product ratio depends on the nature of the α-halogen atom and the solvent.
Tetrakis(dimethylamino)ethylene (TDAE) as a useful reductant of some chlorodifluoromethylated ketones. A new approach for the synthesis of α,α- difluoroketone derivatives
Burkholder, Conrad,Dolbier Jr., William R.,Medebielle, Maurice,Ndedi, Alexandre
, p. 8853 - 8856 (2007/10/03)
Tetrakis(dimethylamino)ethylene (TDAE) was found to be an effective reductant of chlorodifluoromethylated ketones 1-3. The generated α,α- difluoroacetyl anion was trapped with several aldehydes 4-7, under mild conditions, to give the corresponding 2,2-difluoro-3-hydroxy ketone derivatives 8-13, in moderate yields.
