219296-24-9

Usage

Uses

Used in Organic Synthesis:
3-(Chlorodifluoroacetyl)imidazo[1,2-a]pyridine is used as a synthetic intermediate for the preparation of various organic compounds. Its unique structure allows for further chemical modifications, making it a valuable building block in the synthesis of complex molecules.
Used in Pharmaceutical Research:
3-(Chlorodifluoroacetyl)imidazo[1,2-a]pyridine is used as a potential candidate for pharmaceutical applications due to its aromaticity and potential biological activities. Its structure may be optimized to develop new drugs with specific therapeutic properties, contributing to the advancement of medicine.
Used in Chemical Research:
3-(Chlorodifluoroacetyl)imidazo[1,2-a]pyridine is used as a subject of study in chemical research to understand its properties, reactivity, and potential applications. This knowledge can be applied to develop new synthetic methods, improve existing ones, or discover novel uses for 3-(Chlorodifluoroacetyl)imidazo[1,2-a]pyridine in various industries.

InChI:InChI=1/C9H5ClF2N2O/c10-9(11,12)8(15)6-5-13-7-3-1-2-4-14(6)7/h1-5H

Upstream product

• 274-76-0 imidazo[1,2-a]pyridine 
• 354-24-5 chlordifluoroacetyl chloride 
• 2834-23-3 chlorodifluoroacetic anhydride 
• 504-29-0 2-aminopyridine 
• 503540-29-2 (Z)-3-bromo-4-ethoxy-1-chloro-1,1-difluorobut-3-en-2-one 

Relevant academic research and scientific papers

Reaction of α-halogen substituted β-ethoxyvinyl trifluoromethyl ketones with 2-aminopyridine: New route to trifluoroacetyl-containing heterocycles

The reaction of α-halosubstituted β-ethoxyvinyl trifluomethyl ketones with 2-aminopyridine gives 3-trifluoroacetyl imidazo [1,2-a]pyridine and 3-halo-1,1,1,-trifluoro-4-(2-pyridinylamino)-3-buten-2-ones. The product ratio depends on the nature of the α-halogen atom and the solvent.

Synthesis and electron-transfer reactions of some 3-difluoroacetylated imidazo[1,2-a]pyridine derivatives

The synthesis of new 3-chlorodifluoroacetylated imidazo[1,2-a]pyridines 1-6 and their difluoroacetyl derivatives is presented. The reductive cleavage of the halogenated ketones was investigated by cyclic voltammetry, and tetrakis(dimethylamino)ethylene (T

Tetrakis(dimethylamino)ethylene (TDAE) as a useful reductant of some chlorodifluoromethylated ketones. A new approach for the synthesis of α,α- difluoroketone derivatives

Tetrakis(dimethylamino)ethylene (TDAE) was found to be an effective reductant of chlorodifluoromethylated ketones 1-3. The generated α,α- difluoroacetyl anion was trapped with several aldehydes 4-7, under mild conditions, to give the corresponding 2,2-difluoro-3-hydroxy ketone derivatives 8-13, in moderate yields.