219297-10-6 Usage
General Description
Boc-(R)-3-Amino-4-(2-naphthyl)-butyric acid is a specialty chemical, often used in scientific research, which belongs to the family of amino acids and peptides. The ‘Boc’ in its name refers to a 'tert-Butyloxycarbonyl' protective group, which is used in chemistry for the temporary protection of amines. Boc-(R)-3-Amino-4-(2-naphthyl)-butyric acid is significant for its distinctive R-alpha configuration, which is linked to its stereochemistry and the arrangement of its atoms in space. Its 2-naphthyl group, a component comprised of a polycyclic aromatic hydrocarbon, is a key structural feature that contributes to its overall physical and chemical properties. While specialty chemicals like Boc-(R)-3-Amino-4-(2-naphthyl)-butyric acid are primarily used in research, they also have potential applications in the pharmaceutical industry for drug design and synthesis.
Check Digit Verification of cas no
The CAS Registry Mumber 219297-10-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,9,2,9 and 7 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 219297-10:
(8*2)+(7*1)+(6*9)+(5*2)+(4*9)+(3*7)+(2*1)+(1*0)=146
146 % 10 = 6
So 219297-10-6 is a valid CAS Registry Number.
InChI:InChI=1/C19H23NO4/c1-19(2,3)24-18(23)20-16(12-17(21)22)11-13-8-9-14-6-4-5-7-15(14)10-13/h4-10,16H,11-12H2,1-3H3,(H,20,23)(H,21,22)/t16-/m1/s1
219297-10-6Relevant articles and documents
Synthesis method of chiral N-Boc-3-amino-4-aryl-butyric acid
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Paragraph 0032; 0033; 0034; 0035; 0042, (2017/08/28)
The invention relates to a synthesis method of chiral N-Boc-3-amino-4-aryl-butyric acid. The method is as below: 1, conducting a cross metathesis reaction, an asymmetric conjugate addition reaction and an oxidation reaction on starting materials including an allyl aromatic compound and crotonaldehyde by a continuous reaction one-pot method to synthesize an N-Boc-3-aryl methyl-5-oxo isoxazole intermediate; or conducting an asymmetric conjugate addition reaction and an oxidation reaction on a starting material (E)-4-aryl-2-crotonaldehyde by a continuous reaction one-pot method to synthesize an N-Boc-3-aryl methyl-5-oxo isoxazole intermediate; and 2, subjecting (3R)-N-Boc-3-aryl methyl-5-oxo isoxazole intermediate by high-pressure hydrogenation to directly prepare the chiral N-Boc-3-amino-4-aryl-butyric acid. The synthesis method provided by the invention has the advantages of simple operation, mild reaction conditions, target product yield reaching 60-69%, and ee value of the target product reaching as high as 96%. The synthetic route has industrialization prospect.
