219298-63-2

Basic information

• Product Name: 2-hydroxy-3-methyl-4-(tetrahydro-2H-pyran-2-yloxy)benzaldehyde
• Synonyms: 2-hydroxy-3-methyl-4-(tetrahydro-2H-pyran-2-yloxy)benzaldehyde
• CAS NO: 219298-63-2
• Molecular Weight: 236.268
• Mol File: 219298-63-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-hydroxy-3-methyl-4-(tetrahydro-2H-pyran-2-yloxy)benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-3-methyl-4-(tetrahydro-2H-pyran-2-yloxy)benzaldehyde(219298-63-2)
• EPA Substance Registry System: 2-hydroxy-3-methyl-4-(tetrahydro-2H-pyran-2-yloxy)benzaldehyde(219298-63-2)

Safety Data

• Hazardous Substances Data: 219298-63-2(Hazardous Substances Data)

Upstream product

• 6248-20-0 2,4-dihydroxy-3-methylbenzaldehyde 
• 608-25-3 2-methylbenzene-1,3-diol 
• 110-87-2 3,4-dihydro-2H-pyran 

Downstream Products

• 219298-64-3 2-methoxy-3-methyl-4-(tetrahydro-2H-pyran-2-yloxy)benzaldehyde 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF 2-SUBSTITUTED-2-(6-(SUBSTITUTED)-7-METHYLBENZO[D][1,3]DIOXOL-4-YL)ACETIC ACID DERIVATIVES

Present invention relates to an improved and commercial process for the preparation of 2-sustituted-2-(6-(substituted)-7-methylbenzo[d][1,3]dioxol-4-yl)acetic acid derivatives of formula-I [Formula should be inserted here], wherein R1 is a O-protecting group such as methoxymethyl, ethoxymethyl, trialkylsilyl, arylmethyl, tetrahydropyran-2-yl, allyl; X is hydroxyl, halogen, mesylate, triflate, tosylate, acetate; Y is oxygen atom, NH or sulfur atom; R2 is C1-C6 alkyl. 2,4-Dihydroxy-3-methylbenzal-dehyde is selectively protected at C-4 position in the form of an ether compound of formula-XII, oxidized the aldehyde function to get the diol of formula-XIII, and condensed with ethyl glyoxalate under Casiraghi reaction conditions to get the compound of formula-XV. Compound of formula-XV is converted to compound of formula-I by conventional chemistry. Compounds of formula-I are key intermediates in the synthesis of ecteinascidines like trabectedin

Biologically active 1,3-bis-aromatic-prop-2-en-1-ones, 1,3-bis-aromatic-propan-1-ones, and 1,3-bis-aromatic-prop-2-yn-1-ones

The invention relates to the use of 1,3-bis-aromatic-prop-2-en-1-ones (chalcones), 1,3-bis-aromatic-propan-1-ones (dihydrochalcones), and 1,3-bis-aromatic-prop-2-yn-1-ones for the preparation of pharmaceutical compositions for the treatment or prophylaxis of a number of serious diseases including i) conditions relating to harmful effects of inflammatory cytokines, ii) conditions involving infection by Helicobacter species, iii) conditions involving infection by viruses, iv) neoplastic disorders, and v) conditions caused by microorganisms or parasites. The invention also relates to novel chalcones and dihydrochalcones (especially alkoxy substituted variants) having advantageous substitution patterns with respect to their effect as drug substances, and to methods of preparing them, as well as to pharmaceutical compositions comprising the novel chalcones. Moreover, the present invention relates to a method for the isolation of Leishmania fumarate reductase, QSAR methodologies for selecting potent compounds for the above-mentioned purposes.