21931-02-2Relevant academic research and scientific papers
MODULATORS OF SESTRIN-GATOR2 INTERACTION AND USES THEREOF
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Paragraph 00263; 00264; 00265, (2018/11/22)
The present invention provides compounds, compositions thereof, and methods of using the same.
MODULATORS OF SESTRIN-GATOR2 INTERACTION AND USES THEREOF
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Paragraph 0378, (2017/05/15)
The present invention provides compounds, compositions thereof, and methods of using the same.
Organocatalysis of asymmetric aldol reaction in water: Comparison of catalytic properties of (S)-valine and (S)-proline amides
Kucherenko,Siyutkin,Dashkin,Zlotin
, p. 1010 - 1015 (2014/03/21)
(S)-Valine amides containing (S)- or (R)-α-phenylethyl substituents at N1 atom efficiently catalyze asymmetric aldol reactions between cyclic (heterocyclic) ketones and aromatic aldehydes in water, predominantly giving rise to the aldol anti-di
A convenient synthesis of amino acid arylamides utilizing methanesulfonyl chloride and N-methylimidazole
Mao, Liguang,Wang, Zhenyu,Li, Yongjia,Han, Xiqian,Zhou, Weicheng
supporting information; experimental part, p. 129 - 133 (2011/03/22)
N-Cbz-protected amino acids reacted with various aryl-amines in the presence of methanesulfonyl chloride and N-methylimidazole in dichloromethane to give the corresponding arylamides in high yields. No obvious racemization was observed under the mild conditions. Georg Thieme Verlag Stuttgart - New York.
A novel generation of coupling reagents. Enantiodifferentiating coupling reagents prepared in situ from 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) and chiral tertiary amines
Kaminski,Kolesinska,Kaminska,Gora
, p. 6276 - 6281 (2007/10/03)
Coupling of racemic N-protected amino acids with amino components by means of 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) in the presence of chiral tertiary amines such as strychnine, brucine, and sparteine proceeds enantioselectively, affording appropriate amides or dipeptides in 69-85% yield. The configuration of the preferred enantiomer and enantiomeric enrichment depend on the structures of the amine and carboxylic acid. Calculated Kagan enantioselectivity parameters (s) are in the range 1.6-195. Chiral triazinylammonium chlorides formed in situ from CDMT and chiral tertiary amines are postulated as reactive intermediates involved in the process of enantioselective activation of N-protected amino acids.
Recognition of quaternary ammonium salts with tetrapeptides containing α-aminoisobutyric acid as a conformational constraint
Yanagihara, Ryoji,Katoh, Masaki,Hanyuu, Masayuki,Miyazawa, Toshifumi,Yamada, Takashi
, p. 551 - 556 (2007/10/03)
Tetrapeptides Trp-Aib-Gly-Leu-NH-Ar (Aib:α-aminoisobutyric acid, 2-amino-2-methylpropanoic acid, Ar = phenyl or 3,5-dimethylphenyl) were synthesized. The peptides bound quaternary ammonium salts as guests in CDCl3. For every guest, the binding constant K of the peptide host which has a 3,5-dimethylphenyl group was larger than that of the host which has a phenyl group. ROESY analysis of the complex revealed that the N+-CH3 groups of the guests were close to the aromatic moieties of the host in the complex. The charge in cation guests, the φ-basicity of the host, and the turn conformation of the peptides were important factors for the complexation.
