21934-29-2

Basic information

• Product Name: (16E)-16-[(acetyloxy)methylidene]-17-oxoandrost-5-en-3-yl acetate
• CAS NO: 21934-29-2
• Molecular Formula: C₂₄H₃₂O₅
• Molecular Weight: 400.5079
• Mol File: 21934-29-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 496.1°C at 760 mmHg
• Flash Point: 212.9°C
• Density: 1.17g/cm³
• Vapor Pressure: 5.56E-10mmHg at 25°C
• Refractive Index: 1.549
• CAS DataBase Reference: (16E)-16-[(acetyloxy)methylidene]-17-oxoandrost-5-en-3-yl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: (16E)-16-[(acetyloxy)methylidene]-17-oxoandrost-5-en-3-yl acetate(21934-29-2)
• EPA Substance Registry System: (16E)-16-[(acetyloxy)methylidene]-17-oxoandrost-5-en-3-yl acetate(21934-29-2)

Safety Data

• Hazardous Substances Data: 21934-29-2(Hazardous Substances Data)

Usage

Description

(16E)-16-[(acetyloxy)methylidene]-17-oxoandrost-5-en-3-yl acetate is a complex steroid compound derived from androstenedione. It features an acetate group at the C3 position and an acetyloxy group at the C16 position, playing a role in physiological processes such as sex hormone regulation and the development of secondary sexual characteristics.

Uses

Used in Pharmaceutical Industry:
(16E)-16-[(acetyloxy)methylidene]-17-oxoandrost-5-en-3-yl acetate is used as a hormone modulator for its involvement in the regulation of sex hormones and the development of secondary sexual characteristics. Its potential pharmaceutical applications include hormone replacement therapy and as a precursor in the synthesis of other steroid hormones, making it a valuable compound in the development of treatments for various hormonal imbalances and related conditions.

Upstream product

• 2405-43-8 3β-hydroxy-16-(hydroxymethylene)androst-5-en-17-one 
• 108-24-7 acetic anhydride 
• 853-23-6 prasterone acetate 
• 475233-14-8 3β-hydroxy-16-hydroxymethylene-5-androsten-17-one 
• 3552-88-3 16-formyl-3β-hydroxy-5-androsten-17-one 

Downstream Products

• 1310052-07-3 3β-acetoxy-16β-(4-phenyl-1H-1,2,3-triazol-1-ylmethyl)androst-5-en-17β-ol 
• 1310052-28-8 3β-acetoxy-16β-[4-(4-ethylphenyl)-1H-1,2,3-triazol-1-ylmethyl]androst-5-en-17β-ol 
• 1310052-29-9 3β-acetoxy-16β-[4-(3-tolyl)-1H-1,2,3-triazol-1-ylmethyl]androst-5-en-17β-ol 
• 1310052-30-2 3β-acetoxy-16β-[4-(4-tert-butylphenyl)-1H-1,2,3-triazol-1-ylmethyl]androst-5-en-17β-ol 
• 1310052-31-3 3β-acetoxy-16β-[4-(4-methoxyphenyl)-1H-1,2,3-triazol-1-ylmethyl]androst-5-en-17β-ol 
• 1310052-32-4 3β-acetoxy-16β-[4-(2-methoxyphenyl)-1H-1,2,3-triazol-1-ylmethyl]androst-5-en-17β-ol 
• 1310052-33-5 3β-acetoxy-16β-[4-(4-fluorophenyl)-1H-1,2,3-triazol-1-ylmethyl]androst-5-en-17β-ol 
• 1310052-34-6 3β-acetoxy-16β-[4-(3-aminophenyl)-1H-1,2,3-triazol-1-ylmethyl]androst-5-en-17β-ol 
• 1310052-08-4 16β-(4-phenyl-1H-1,2,3-triazol-1-ylmethyl)androst-5-ene-3β,17β-diol 
• 1310052-15-3 16β-[4-(4-ethylphenyl)-1H-1,2,3-triazol-1-ylmethyl]androst-5-ene-3β,17β-diol 
• 62201-86-9 16β-p-toluenesulfonyloxymethylandrost-5-ene-3β,17β-diol 3-acetate 
• 1310052-14-2 16β-(5-benzoyl-1H-tetrazol-1-ylmethyl)androst-5-ene-3β,17β-diol 
• 1310052-12-0 16β-(5-benzyloxycarbonyl-1H-tetrazol-1-ylmethyl)androst-5-ene-3β,17β-diol 
• 1310052-27-7 3β-acetoxy-16β-(5-benzoyl-1H-tetrazol-1-ylmethyl)androst-5-en-17β-ol 

Relevant articles and documents

Synthesis and in vitro antiproliferative activity of novel androst-5-ene triazolyl and tetrazolyl derivatives

A straightforward and reliable method for the regioselective synthesis of steroidal 1,4-disubstituted triazoles and 1,5-disubstituted tetrazoles via copper(I)-catalyzed cycloadditions is reported. Heterocycle moieties were efficiently introduced onto the starting azide compound 3β-acetoxy- 16β-azidomethylandrost-5-en-17β-ol through use of the "click" chemistry approach. The antiproliferative activities of the newly-synthesized triazoles were determined in vitro on three human gynecological cell lines (HeLa, MCF7 and A2780) using the microculture tetrazolium assay.