21934-29-2Relevant academic research and scientific papers
Synthesis and in vitro antiproliferative activity of novel androst-5-ene triazolyl and tetrazolyl derivatives
Kadar, Zalan,Kovacs, Dora,Frank, Eva,Schneider, Gyula,Huber, Judit,Zupko, Istvan,Bartok, Tibor,Woelfling, Janos
experimental part, p. 4786 - 4806 (2011/09/12)
A straightforward and reliable method for the regioselective synthesis of steroidal 1,4-disubstituted triazoles and 1,5-disubstituted tetrazoles via copper(I)-catalyzed cycloadditions is reported. Heterocycle moieties were efficiently introduced onto the starting azide compound 3β-acetoxy- 16β-azidomethylandrost-5-en-17β-ol through use of the "click" chemistry approach. The antiproliferative activities of the newly-synthesized triazoles were determined in vitro on three human gynecological cell lines (HeLa, MCF7 and A2780) using the microculture tetrazolium assay.
The hydrogenation of alpha-hydroxymethylene-ketone derivatives to alpha-hydroxymethyl-ketone derivatives with a cell-free system of Streptomyces cinereocrocatus.
Oda,Sato,Sato
, p. 502 - 505 (2007/10/02)
2',3'-Dihydro-5'-formylgriseofulvin (3), oxymetholone (5), and 3 beta-acetoxy-16-acetoxymethylene-5-androsten-17-one (9) were used as the substrates of a cell-free system from Streptomyces cinereocrocatus NRRL 3443. The results indicated that S. cinereocrocatus contains enzymatic activities which reduce the above three alpha-hydroxymethylene-ketones to the corresponding alpha-hydroxymethyl-ketones.
