21944-46-7Relevant academic research and scientific papers
A versatile synthesis of 3-phenylsulfonylpyrroles from α-amino acids
Burley,Hewson
, p. 1151 - 1154 (2007/10/02)
Reaction between α-benzamidoalkyl ketones 4a-e and the vinyl phosphonium salt 1 produces 3-phenylthio-3-pyrrolines 5a-e which can be converted into N-benzyl-3-phenylsulfonyl pyrroles 7a-e by m-CPBA oxidation, diborane reduction and DDQ aromatisation.
PHOSPHORUS-CONTAINING HMG-COA REDUCTASE INHIBITORS, NEW INTERMEDIATES AND METHOD
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, (2008/06/13)
Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesteroleumic agents are provided which have the structure STR1 wherein R is OH, or salts thereof or lower alkoxy; R. sup.x is H or alkyl;X is--CH 2--,--
Imidazole analogs of mevalonolactone and derivatives thereof for use in inhibiting cholesterol biosynthesis and lowering blood cholesterol level
-
, (2008/06/13)
Compounds of the formula STR1 and the pharmaceutically acceptable acid addition salts thereof, wherein the various substituents are defined hereinbelow and the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis, pharmaceutical compositions comprising such compounds and processes for and intermediates in the synthesis of such compounds.
Intermediate imidazole acrolein analogs
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, (2008/06/13)
Compounds of the formula STR1 and the pharmaceutically acceptable acid addition salts thereof, wherein the various substituents are defined hereinbelow, the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis, pharmaceutical compositions comprising such compounds and processes for and intermediates in the synthesis of such compounds.
