21948-10-7 Usage
Uses
Used in Pharmaceutical Industry:
O-Benzyl-(D)-serine benzyl ester is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to protect peptide bonds, thereby increasing the stability of the final drug product.
Used in Peptide-based Pharmaceutical Production:
O-Benzyl-(D)-serine benzyl ester is used as a building block for the synthesis of complex peptide-based pharmaceutical compounds, contributing to the development of innovative treatments and therapies.
Used as a Protecting Group in Organic Synthesis:
In the context of organic synthesis, O-Benzyl-(D)-serine benzyl ester serves as a protecting group for serine residues during the synthesis process, ensuring the selective reactivity of other functional groups and facilitating the formation of desired pharmaceutical compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 21948-10-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,9,4 and 8 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 21948-10:
(7*2)+(6*1)+(5*9)+(4*4)+(3*8)+(2*1)+(1*0)=107
107 % 10 = 7
So 21948-10-7 is a valid CAS Registry Number.
InChI:InChI=1/C17H19NO3/c18-16(13-20-11-14-7-3-1-4-8-14)17(19)21-12-15-9-5-2-6-10-15/h1-10,16H,11-13,18H2/t16-/m0/s1
21948-10-7Relevant academic research and scientific papers
AMINO ACIDS; 13. INVESTIGATIONS ON THE SYNTHESIS OF DL-SERINE FROM α-HALOACRYLIC ACID DERIVATIVES
Effenberger, Franz,Zoller, Gerhard
, p. 5573 - 5582 (2007/10/02)
The alkoxide-catalyzed addition of alcohols 2 to α-chloroacrylonitrile (1) at -35 degC gives rise to 3-alkoxy-2-chloropropanenitriles 3; at 0-5 degC with excess 2 alkyl 3-alkoxy-2-chloropropanimidates 4 are obtained.The yields of 3 or 4 decrease with increasing pKa values of the alcohols 2.In the basecatalyzed addition of phenols 5 to 1, a temperature-dependent addition equilibrium is set up in which the position of equilibrium is shifted in favour of the addition products 6 with increasing pKa values of 5.The 3-alkoxy-2-chloropropanoates 8, which are readily accessible by hydrolysis of 4, react smoothly with sodium azide in the presence of a phase transfer catalyst to furnish the 3-alkoxy-2-azidopropanoates 10.Starting from benzyl 2-azido-3-benzyloxy-propanoate (10b), the specific syntheses of DL-serine (14), DL-serine hydrochloride (14*HCl), DL-serine methyl ester hydrochloride (13a*HCl), O-benzyl-DL-serine (12b), and O-benzyl-DL-serine benzyl ester hydrochloride (11b*HCl) are possible by variation of the hydrogenation conditions.
