219480-94-1Relevant articles and documents
Synthesis and alkylation of pyridylacetylenes under phase transfer catalysis conditions in a liquid/solid system
Abele,Abele,Ruhina,Gaukhman,Lukevics
, p. 459 - 462 (1998)
We have investigated the alkylation of 2-methyl-5-ethynylpyridine by butyl bromide in liquid/liquid and liquid/solid two-phase catalytic systems. We have shown that the catalytic system solid KOH/18-crown-6/CuBr/toluene is the most active in this reaction; using this system, we obtained alkylation products of ethynylpyridines in 34-43% yields. 1998 Plenum Publishing Corporation.