219492-01-0

Basic information

• Product Name: N-(2-aminophenyl)-3-cyanobenzamide
• Synonyms: N-(2-aminophenyl)-3-cyanobenzamide
• CAS NO: 219492-01-0
• Molecular Formula: C₁₄H₁₁N₃O
• Molecular Weight: 237.261
• Mol File: 219492-01-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(2-aminophenyl)-3-cyanobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-aminophenyl)-3-cyanobenzamide(219492-01-0)
• EPA Substance Registry System: N-(2-aminophenyl)-3-cyanobenzamide(219492-01-0)

Safety Data

• Hazardous Substances Data: 219492-01-0(Hazardous Substances Data)

Upstream product

• 1711-11-1 3-cyanobenzoyl chloride 
• 88-74-4 2-nitro-aniline 
• 1877-72-1 3-Cyanobenzoic acid 
• 95-54-5 1,2-diamino-benzene 
• 219492-00-9 N-(3-cyanobenzoyl)-2-nitroaniline 

Downstream Products

• 219492-02-1 N¹-(3-cyanobenzoyl)-N²-(4-t-butylbenzoyl)-1,2-benzenediamine 
• 219519-99-0 N¹-(3-(amino(hydroxyimino)methyl)benzoyl)-N²-(4-ethoxybenzoyl)-1,2-benzenediamine 
• 219519-15-0 N¹-(3-(amino(hydroxyimino)methyl)benzoyl)-N²-(4-iso-propylbenzoyl)-1,2-benzenediamine 
• 303134-35-2 3-cyano-N-(2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}phenyl)benzamide 
• 219519-98-9 N¹-(3-cyanobenzoyl)-N²-(4-ethoxybenzoyl)-1,2-benzenediamine 
• 219519-14-9 N¹-(3-cyanobenzoyl)-N²-(4-iso-propylbenzoyl)-1,2-benzenediamine 

Relevant articles and documents

Synthesis and biological activity of novel 1,2-disubstituted benzene derivatives as factor Xa inhibitors

Factor Xa (fXa) is a serine protease that plays a pivotal role in the coagulation cascade. High-throughput screening of the Yamanouchi compound library yielded lead compound 1 with the ability to inhibit fXa at micromolar concentrations. To improve its fX

Antithrombotic agents

This application relates to a compound of formula (I), a pharmaceutically acceptable salt of the compound, or a prodrug thereof, as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.