219496-66-9Relevant academic research and scientific papers
Synthesis of d-camphor based γ-amino acid (1S,3R)-3-amino-2,2,3-trimethylcyclopentane carboxylic acid
Eagles, Joel B.,Hitchcock, Shawn R.
, p. 519 - 523 (2010)
Synthesis of a γ-amino acid derived from (1R,3S)-camphoric acid is described. d-(+)-Camphoric anhydride, prepared from d-(+)-camphoric acid by treatment with methanesulfonyl chloride and triethylamine, was reacted with benzyl alcohol and catalytic DMAP, and subsequently reacted in a Curtius rearrangement to afford the corresponding carbamate derivative. This derivative was converted to the desired γ-amino acid through hydrogenolysis.
Total synthesis of a possible specific and effective acid-targeted cancer diagnostic, a camphor derived bis-N-oxide dimer
Boeckman Jr., Robert K.,Miller, Yan,Savage, Dennis,Summerton, James E.
supporting information; experimental part, p. 2243 - 2245 (2011/05/05)
Possible specific and effective acid-targeted cancer diagnostics and therapeutics, a camphor derived bis-N-oxide dimer was synthesized in 12-steps from commercially available (+)-camphoric acid and seven-steps from a common intermediate, a camphor derived primary amine.
