219517-92-7Relevant academic research and scientific papers
Cp2VCl2-catalyzed meso-selective pinacol coupling reaction of aldimines in the presence of chlorosilane and zinc metal
Hatano, Bunpei,Ogawa, Akiya,Hirao, Toshikazu
, p. 9421 - 9424 (1998)
A catalytic reductive coupling of aldimines was achieved by using a catalyst Cp2VCl2/PhMe2SiCl/Zn system. The influence of the catalyst, chlorosilane, co-reductant, solvent, and temperature on both the yield and diastereoselectivity of the coupling products was investigated in detail. As a result, the present Cp2VCl2-catalyzed reductive coupling of aldimines in the presence of PhMe2-SiCl and zinc metal provided the corresponding 1,2- diamines in good yield with high meso selectivity (up to 92% meso), while the reductive coupling of aldehydes, ketones, and aldimines by the hitherto known catalytic methods leads to the preferential formation of dl isomers of the coupling products.
