219539-65-8Relevant academic research and scientific papers
Analogues of a locked nucleic acid with three-carbon 2′,4′- linkages: Synthesis by ring-closing metathesis and influence on nucleic acid duplex stability and structure
Albaek, Nanna,Petersen, Michael,Nielsen, Poul
, p. 7731 - 7740 (2006)
(Chemical Equation Presented) Two bicyclic 2′-deoxynucleoside analogues containing a saturated and an unsaturated three-carbon 2′,4′-linkage, respectively, have been synthesized using a ring-closing metathesis-based linear strategy starting from uridine.
Two carbocyclic locked nucleic acid analogues give structural information about the role of hydration in A-type duplexes
Albaek, Nanna,Petersen, Michael,Nielsen, Poul
, p. 1529 - 1532 (2008/09/18)
Two locked nucleic acid (LNA) analogues with three-carbon 2′-4′ linkages, saturated or unsaturated, are synthesized using a ring-closing metathesis based strategy. Strongly stabilized duplexes with complementary RNA and slightly destabilized duplexes with
