21954-74-5

Usage

Uses

Used in Medical Field:
Ethonium is used as a disinfectant and antiseptic agent for sterilizing and disinfecting skin, medical instruments, and surgical equipment. It is effective against a wide range of microorganisms, making it a valuable asset in wound care and surgical procedures to reduce the risk of infection.
Used in Wound Care:
Ethonium is used as a wound care agent to prevent infection and promote healing. Its broad-spectrum antimicrobial activity helps to reduce the risk of infection in various types of wounds, including surgical incisions, burns, and other skin injuries.
Used in Surgical Procedures:
Ethonium is used as a surgical antiseptic to minimize the risk of infection during surgical procedures. Its application on the skin and surgical instruments helps to create a sterile environment, ensuring patient safety and reducing postoperative complications.
Used in Anticancer Research:
Ethonium has been studied for its potential use as an anti-cancer agent due to its ability to inhibit DNA synthesis and cell growth. Although still in the research phase, its properties may offer new therapeutic approaches for cancer treatment.
It is crucial to use Ethonium with caution and according to proper guidelines, as it can be toxic if ingested or absorbed through damaged skin.

Synthetic route

N,N,N,N,-tetramethylethylenediamine (110-18-9) + decyl chloroacetate (6974-05-6) → ethonium (21954-74-5)

Conditions	Yield
With potassium iodide; sodium hydroxide In ethanol for 8h; Reflux;	85%
In benzene

1-Decanol (112-30-1) → ethonium (21954-74-5)

Conditions	Yield
Multi-step reaction with 2 steps 1: aq. H2SO4 2: benzene View Scheme
Multi-step reaction with 2 steps 1: toluene-4-sulfonic acid / benzene / Reflux 2: potassium iodide; sodium hydroxide / ethanol / 8 h / Reflux View Scheme

Upstream product

• 112-30-1 1-Decanol 
• 110-18-9 N,N,N,N,-tetramethylethylenediamine 
• 6974-05-6 decyl chloroacetate 

Relevant academic research and scientific papers

Synthesis and surface active properties of gemini cationic surfactants and interaction with anionic azo dye (AR52)

A homologous series of new gemini cationic surfactants were synthesized and characterized using micro elemental analysis, FTIR, 1H-NMR and mass spectra. The surface activities of these amphiphiles were determined based on the data of surface tension. Critical micelle concentration, effectiveness of the surface tension reduction, efficiency of adsorption, maximum surface excess, minimum surface area and critical packing parameter were evaluated. The effect of cationic micelles on solubilization of anionic azo dye, sulforhodamine B (Acid Red 52) in aqueous micellar solution of the synthesized gemini cationic surfactants was studied at pH 6.9 ± 0.5 and 25°C. The results showed that the solubility of dye rose with increasing surfactant concentration as a consequence of some association between the dye and the micelles. It was also observed that the aggregation of surfactant and dye takes place at a surfactant concentration below the CMC of the individual surfactant. The partition coefficients between the bulk water and surfactant micelles as well as the Gibbs energies of distribution of dye between the bulk water and surfactant micelles were calculated using a pseudo-phase model. The effect of the hydrophobic chain length of Gemini cationic surfactants on the distribution parameters was also reported. The results show favorable solubilization of dye in cationic micelles. AOCS 2011.