219544-54-4Relevant academic research and scientific papers
Synthetic N-pyridinyl(methyl)-indol-3-ylpropanamides as new potential immunosuppressive agents
Carbonnelle, Delphine,Lardic, Morgane,Dassonville, Alexandra,Verron, Elise,Petit, Jean-Yves,Duflos, Muriel,Lang, Francois
, p. 686 - 693 (2007)
Several N-pyridinyl(methyl)-indol-3-ylpropanamides were synthesized and pharmacological evaluations of their immunosuppressive potential were performed. Among thirteen compounds tested in vitro on murine T proliferation, three showed interesting inhibitin
Synthesis of N-aryl-3-(indol-3-yl)propanamides and their immunosuppressive activities
Giraud, Francis,Marchand, Pascal,Carbonnelle, Delphine,Sartor, Michael,Lang, Fran?ois,Duflos, Muriel
scheme or table, p. 5203 - 5206 (2010/10/03)
N-Aryl-3-(indol-3-yl)propanamides were synthesized and their immunosuppressive activities were evaluated. This study highlighted the promising potency of 3-[1-(4-chlorobenzyl)-1H-indol-3-yl]-N-(4-nitrophenyl) propanamide 15 which exhibited a significant i
New N-pyridinyl(methyl)-indolalkanamides acting as topical inflammation inhibitors
Dassonville, Alexandra,Bretéché, Anne,Evano, Johan,Duflos, Muriel,Le Baut, Guillaume,Grimaud, Nicole,Petit, Jean-Yves
, p. 5441 - 5444 (2007/10/03)
The authors have described the synthetic way to new N-pyridinyl(methyl) indolylpropanamides acting as non acidic NSAIDs. Pharmacomodulation was carried out at N-1 and C-5 of the indole ring and at the level of the propanamide chain. N-(pyridin-3-ylmethyl)-3-[5-chloro-1-(4-chlorobenzyl)-indol-3-yl]propanamide 32 represents one of the most potent compounds evaluated in the TPA-induced mouse ear swelling assay, with a level of activity higher than that of ibuprofen and comparable to that of dexamethasone.
(1-Benzylindole-3-yl)alkanoic acids; novel nonsteroidal inhibitors of steroid 5α-reductase (I)
Sawada, Kozo,Hirai, Hideo,Golden, Patrick,Okada, Satoshi,Sawada, Yuki,Hashimoto, Masashi,Tanaka, Hirokazu
, p. 1683 - 1687 (2007/10/03)
A novel series of indole-3-alkanoic acids with varied N-benzyl substituents were synthesized as nonsteroidal inhibitors of steroid 5α- reductase. The structure-activity relationships in this series were studied and the optimum carboxylic acid side chain w
