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2196-60-3

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2196-60-3 Usage

Chemical Properties

Coclaurine is a white crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents.

Uses

Coclaurine is a tetrahydroisoquinoline alkaloid with anti-aging activity,used as a nicotinic acetylcholine receptor antagonis.

Check Digit Verification of cas no

The CAS Registry Mumber 2196-60-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,1,9 and 6 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 2196-60:
(6*2)+(5*1)+(4*9)+(3*6)+(2*6)+(1*0)=83
83 % 10 = 3
So 2196-60-3 is a valid CAS Registry Number.
InChI:InChI=1/C17H19NO3/c1-21-17-9-12-6-7-18-15(14(12)10-16(17)20)8-11-2-4-13(19)5-3-11/h2-5,9-10,15,18-20H,6-8H2,1H3/t15-/m1/s1

2196-60-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name (R)-coclaurine

1.2 Other means of identification

Product number -
Other names R-Coclaurin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2196-60-3 SDS

2196-60-3Synthetic route

(+)-1-(R)-coclaurine
2196-60-3

(+)-1-(R)-coclaurine

acetic anhydride
108-24-7

acetic anhydride

Acetic acid (R)-1-(4-acetoxy-benzyl)-2-acetyl-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-7-yl ester
3422-43-3, 96370-47-7

Acetic acid (R)-1-(4-acetoxy-benzyl)-2-acetyl-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-7-yl ester

Conditions
ConditionsYield
With pyridine for 15h; Ambient temperature;
(+)-1-(R)-coclaurine
2196-60-3

(+)-1-(R)-coclaurine

S-(5’-adenosyl)-L-methionine chloride

S-(5’-adenosyl)-L-methionine chloride

(-)-(R)-(N)-methylcoclaurine
5096-70-8

(-)-(R)-(N)-methylcoclaurine

Conditions
ConditionsYield
With potassium phosphate buffer; sodium L-ascorbate; coclaurine N-methyltransferase In water at 30℃; for 1h; pH=7.0; Kinetics; Further Variations:; relative activity (vs (S)-coclaurine);

2196-60-3Upstream product

2196-60-3Downstream Products

2196-60-3Related news

The crystal structure of Coclaurine (cas 2196-60-3) hydrobromide monohydrate and the absolute configuration of Coclaurine (cas 2196-60-3)07/15/2019

The structure and absolute configuration of coclaurine has been determined by X-ray analysis of its hydrobromide monohydrate. The (+)-enantiomer has the D-configuration. The chirality of the molecular structure is correlated with circular dichroism measurements.detailed

Purification and characterization of Coclaurine (cas 2196-60-3) N-methyltransferase from cultured Coptis japonica cells07/13/2019

S-Adenosyl-l-methionine (SAM): coclaurine N-methyltransferase (CNMT), which catalyzes the transfer of a methyl group from S-adenosyl-l-methionine to the amino group of the tetrahydrobenzylisoquinoline alkaloid coclaurine, was purified 340-fold from Coptis japonica cells in 1% yield to give an al...detailed

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