219623-06-0Relevant academic research and scientific papers
Iodolactonization of 3-Alkynylthiophene-2-Carboxylic and 3-Alkynylpicolinic Acids for the Synthesis of Fused Heterocycles
Gabriele, Bartolo,Mancuso, Raffaella,Novello, Mariangela,Palumbo Piccionello, Antonio,Russo, Patrizio
, (2020/06/17)
The iodolactonization of 3-alkynylthiophene-2-carboxylic acids and 3-alkynylpicolinic acids has been investigated. Using I2 as the iodine source and NaHCO3 as the base in MeCN, the process took place smoothly to afford thienopyranone
Synthesis of heterocyclic dipeptide analogues
Falck-Pedersen, Mette Lene,Undheim, Kjell
, p. 1327 - 1332 (2007/10/03)
Synthesis of constrained mimics of a serine dipeptide is described. Triflated 3-hydroxypicolinic acid methyl ester was carbo-substituted using ethynylstannanes with Pd-catalysis to furnish 3-acetylenic pyridines which were hydrolysed and coupled to Ser(t-Bu)OMe before cyclization to 1-alkylidene-3-oxo-1,3-dihydro-pyrrolo[3,4-b]pyridine derivatives. Subsequent deprotection provided the dipeptide analogue. Acta Chemica Scandinavica 1998.
