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Pyridazine, 3-methyl-6-(1-piperazinyl)- (9CI) is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

219635-87-7

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219635-87-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 219635-87-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,9,6,3 and 5 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 219635-87:
(8*2)+(7*1)+(6*9)+(5*6)+(4*3)+(3*5)+(2*8)+(1*7)=157
157 % 10 = 7
So 219635-87-7 is a valid CAS Registry Number.

219635-87-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-methyl-6-piperazin-1-ylpyridazine

1.2 Other means of identification

Product number -
Other names F1967-0822

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:219635-87-7 SDS

219635-87-7Downstream Products

219635-87-7Relevant academic research and scientific papers

Synthesis and evaluation of pyridazinylpiperazines as vanilloid receptor 1 antagonists

Tafesse, Laykea,Sun, Qun,Schmid, Lori,Valenzano, Kenneth J.,Rotshteyn, Yakov,Su, Xin,Kyle, Donald J.

, p. 5513 - 5519 (2004)

A series of pyridazinylpiperazines were synthesized and evaluated for VR1 antagonist activity in order to improve upon the pharmaceutical and pharmacological properties of BCTC. A structurally biased chemical library of pyridazinylpiperazine analogs was prepared in an effort to improve the pharmaceutical and pharmacological profile of the lead compound N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H) -carboxamide (BCTC). The library was evaluated for VR1 antagonist activity in capsaicin-induced (CAP) and pH 5.5-induced (pH) FLIPR assays in a human VR1-expressing HEK293 cell line. The most potent VR1 antagonists were found to have IC50 values in the range of 9-200 nM with improved pharmaceutical and pharmacological profiles versus the lead BCTC. These compounds represent possible second-generation BCTC analogs.

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