219657-90-6Relevant articles and documents
Synthesis of imidazo[2,1-b][2H-1,3,4]thiadiazines and 1,2,4-triazolo[3,4-b][2H-1,3,4]thiadiazines
Knak, Stefanie,Pfeiffer, Wolf-Diethard,Dollinger, Horst,Saghyan, Ashot S.,Langer, Peter
, p. 463 - 467 (2015/03/30)
Imidazo[2,1-b][2H-1,3,4]thiadiazines were prepared by cyclization of 2-amino-5-(4-chlorophenyl)-6H-1,3,4-thiadiazine with α-haloketones. 1,2,4-Triazolo[3,4-b][2H-1,3,4]thiadiazines were prepared by cyclization of 4-amino-5-sulfanyl-l,2,4-triazoles with ph
Structure-based design and synthesis of potent matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffold
Schr?der,Henke,Wenzel,Brandstetter,Stammler,Stammler,Pfeiffer,Tschesche
, p. 3231 - 3243 (2007/10/03)
We describe a new generation of heterocyclic nonpeptide matrix metalloproteinase (MMP) inhibitors derived from a 6H-1,3,4-thiadiazine scaffold. A screening effort was utilized to identify some chiral 6-methyl-1,3,4-thiadiazines that are weak inhibitors of
