219679-00-2Relevant articles and documents
Antimitotic agents interacting with tubulin: Synthesis and structure- activity relationships of novel ortho bridged biphenyis of the rhazinilam type
Pascal, Cecile,Dubois, Joelle,Guenard, Daniel,Tchertanov, Luba,Thoret, Sylviane,Gueritte, Francoise
, p. 14737 - 14756 (2007/10/03)
Several new ortho bridged biphenyls mimicking the structure of (-)- rhazinilam were synthesized and evaluated as cytotoxic compounds and as inhibitors of microtubules disassembly. These included azadibenzo[a,c]cyclononene derivatives having an ester, urea