21968-07-0Relevant articles and documents
Sequential Alkene Isomerization and Ring-Closing Metathesis in Production of Macrocyclic Musks from Biomass
Sytniczuk, Adrian,Forcher, Gwéna?l,Grotjahn, Douglas B.,Grela, Karol
supporting information, p. 10403 - 10408 (2018/07/31)
We report successful utilization of sequential alkene isomerization and ring-closing metathesis of dec-9-enoic acid based dienes in synthesis of macrocyclic lactones that possess a strong scent of musk. This catalytic sequence was essential to trim the chain length of starting dienes to yield macrocycles of the right size. Dec-9-enoic acid is conveniently obtainable from oleic esters by Ru-catalysed ethenolysis.