219703-45-4

Upstream product

• 545-06-2 trichloroacetonitrile 
• 219703-44-3 acetic acid 8-acetoxy-6-[2-benzyloxymethyl-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-6-hydroxy-4-(3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3-yloxy]-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester 
• 219703-42-1 acetic acid 8-acetoxy-6-[6-allyloxy-2-benzyloxymethyl-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-4-(3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3-yloxy]-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester 
• 219703-41-0 Acetic acid (2S,4aR,6S,7R,8S,8aS)-8-acetoxy-6-[(2R,3S,4R,5R,6R)-6-allyloxy-2-benzyloxymethyl-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-4-hydroxy-tetrahydro-pyran-3-yloxy]-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester 
• 129753-04-4 O-(2,3-di-O-acetyl-4,6-O-benzylidene-α-D-galactopyranosyl) trichloroacetimidate 
• 107823-72-3 allyl 6-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranoside 
• 33639-77-9 perbenzyl fucosyl bromide 

Relevant academic research and scientific papers

Synthesis of dimeric Lewis X antigenic determinant with azido-type spacer arm by a sequence of regioselective glycosylation steps

A new regioselective glycosylation strategy was used to develop a highly efficient synthesis of the dimeric Lewis X determinant linked to an azido type spacer arm. Regioselective galactosylation of 3,4 glucosamine diols 2 and 3 with galactose donor 4, followed by fucosylation provided two trisaccharide building blocks 9 and 10. The final condensation involved a 3b- regioselective glycosylation of the 2b,3b trisaccharide diol 11 in good yields.