219715-60-3Relevant academic research and scientific papers
Preparation method of triazolopyrimidine herbicide
-
Paragraph 0055-0061, (2020/06/20)
The invention belongs to the technical field of organic synthesis, and particularly relates to a preparation method of a triazolopyrimidine herbicide. The preparation method specifically comprises thefollowing steps: a) reacting a compound with the structure represented by formula (I) with thiosemicarbazide, and then isomerizing under an alkaline condition to obtain a compound with the structurerepresented by formula (II); b) carrying out a diazotization reaction on the compound of the formula (II) and sodium nitrite, and then mixing and reacting with sodium hydrogen sulfite and chloride toobtain a compound with the structure represented by formula (III), wherein the chloride comprises copper chloride and/or cuprous chloride; and c) reacting the compound of the formula (III) with a compound with the structure represented by formula (IV) to obtain the triazolopyrimidine herbicide with the structure represented by formula (V). The preparation method provided by the invention has the advantages of mild reaction conditions, low safety risk and good environmental friendliness.
