219725-68-5

Upstream product

• 33301-41-6 1-benzhydryl-3-azetidinyl methanesulfonate 
• 112275-50-0 tert-butyl 1,4-diazepine-1-carboxylate 

Downstream Products

• 917609-93-9 tert-butyl 4-{1-[(3S)-4-[[(3-cyano-5,6,7,8-tetrahydronaphthalen-1-yl)carbonyl]-(methyl)amino]-3-(4-fluorophenyl)butyl]azetidin-3-yl}-1,4-diazepane-1-carboxylate 

Relevant academic research and scientific papers

NEW AZETIDINE DERIVATIVES AS NEUROKININ RECEPTOR ANTAGONISTS FOR THE TREATMENT OF GASTROINTESTINAL DISEASES

The present invention relates to new azetidine derivatives of formula I, to pharmaceutical compositions containing said compounds and to the use of said compounds as neurokinin (NK) receptor antagonists in the treatment of gastrointestinal diseases. The invention further relates to processes for the preparation of compounds of formula I and to new intermediates used in the preparation thereof .

Azetidinylpropylpiperidine derivatives, intermediates and use as tachykinin antagonists

Compounds of the formula (I): where X1, A, Ar1, X and R are as defined in the specification, and pharmaceutically-acceptable salts thereof, are new, and are useful as tachykinin inhibitors which act at the NK1, NK2and NK3receptors or a combination of two or more thereof.