219735-92-9Relevant academic research and scientific papers
Imidazo[4,5-c]pyridines as corticotropin releasing factor receptor ligands.
Arvanitis, Argyrios G,Rescinito, Joseph T,Arnold, Charles R,Wilde, Richard G,Fitzgerald, Lawrence W,Zaczek, Robert,Hartig, Paul R,Grossman, Scott,Arneric, Stephen P,Gilligan, Paul J,Olson, Richard E,Robertson, David W
, p. 129 - 131 (2007/10/03)
A series of high affinity CRF receptor ligands with an imidazo[4,5-c]pyridine core is described. Individual analogues were synthesized and tested in vitro in rat brain receptors to determine binding affinity. The best compound was further tested in the dog N-in-1 pharmacokinetic model to assess oral bioavailability at 1 mg/kg po.
Imidazopyridines for the treatment of neurological disorders
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Example 38A, (2010/01/31)
Corticotropin releasing factor (CRF) antagonists of formula (I): and their use in treating psychiatric disorders and neurological diseases, anxiety-related disorders, post-traumatic stress disorder, supranuclear palsy and feeding disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress in mammals.
