21974-51-6Relevant articles and documents
Synthesis, structure and properties of oxocyanido W(IV) complexes with substituted salicylaldimines of 2-aminoethanol compared to Mo(IV) analogs
Tomecka, Monika,Szklarzewicz, Janusz,Jurowska, Anna,Wojtczak, Andrzej
, p. 81 - 89 (2014)
A series of W(IV) complexes with 2-aminoethanol and 5-bromo-, 5-chloro-, 5-methoxy-, 3,5 -dichloro-substituted salicylaldehydes is described. The complexes were isolated and characterized by elemental analysis, IR and UV-Vis spectroscopy as well as cyclic
Synthesis, crystal structures, and antibacterial activity of cobalt and copper complexes with tridentate schiff bases
Du, Juan
, p. 1410 - 1414 (2012)
Three mononuclear cobalt and copper complexes, [Co(HL1) 2]·[Co(L1)2] (1), [Cu(HL 2)2] (2), and [CoL2(HL2)] 2 (3), where HL1 and HL2 ar
Mo(IV) and W(IV) cyanido complexes with Schiff bases. Synthesis, X-Ray single crystal structures, physicochemical properties and quantum chemical calculations
Szklarzewicz, Janusz,Skaisgirski, Michael,Paciorek, Patrycja,Kurpiewska, Katarzyna,Zabierowski, Piotr,Radoń, Mariusz
, p. 112 - 121 (2013/12/04)
In the reaction of salicylaldehyde derivatives and aminoethanol with Mo(IV) or W(IV) cyanido complexes, six new salts were isolated and characterized by physicochemical measurements. The single crystal X-ray analysis of four salts of the formula (PPh
Discovery of a novel class of highly potent, selective, ATP-competitive, and orally bioavailable inhibitors of the mammalian target of rapamycin (mTOR)
Takeuchi, Craig S.,Kim, Byung Gyu,Blazey, Charles M.,Ma, Sunghoon,Johnson, Henry W. B.,Anand, Neel K.,Arcalas, Arlyn,Baik, Tae Gon,Buhr, Chris A.,Cannoy, Jonah,Epshteyn, Sergey,Joshi, Anagha,Lara, Katherine,Lee, Matthew S.,Wang, Longcheng,Leahy, James W.,Nuss, John M.,Aay, Naing,Aoyama, Ron,Foster, Paul,Lee, Jae,Lehoux, Isabelle,Munagala, Narsimha,Plonowski, Arthur,Rajan, Sharmila,Woolfrey, John,Yamaguchi, Kyoko,Lamb, Peter,Miller, Nicole
, p. 2218 - 2234 (2013/05/22)
A series of novel, highly potent, selective, and ATP-competitive mammalian target of rapamycin (mTOR) inhibitors based on a benzoxazepine scaffold have been identified. Lead optimization resulted in the discovery of inhibitors with low nanomolar activity and greater than 1000-fold selectivity over the closely related PI3K kinases. Compound 28 (XL388) inhibited cellular phosphorylation of mTOR complex 1 (p-p70S6K, pS6, and p-4E-BP1) and mTOR complex 2 (pAKT (S473)) substrates. Furthermore, this compound displayed good pharmacokinetics and oral exposure in multiple species with moderate bioavailability. Oral administration of compound 28 to athymic nude mice implanted with human tumor xenografts afforded significant and dose-dependent antitumor activity.
Synthesis and structural studies on bis-N-(2-hydroxyethyl)-X-salicylaldiminato complexes of cobalt(III) and copper(II)
Lal, Rajib De,Samanta, Keka,Samanta, Chitra,Mukherjee, Alok K.
, p. 1010 - 1014 (2007/10/03)
Spectroscopic properties and magnetic behaviours of the synthesised cobalt(III) and copper(II) complexes of the schiff bases N-(2-hydroxyethyl-X-salicylaldimines) (where X=H or 5Br) and the molecular structure of bis- (N2-hydroxyethylsalicylaldiminato) co