219745-19-4

Basic information

• Product Name: 3-chloro-3-m-tolylpropan-1-ol
• CAS NO: 219745-19-4
• Molecular Weight: 184.666
• Mol File: 219745-19-4.mol

Chemical Properties

• CAS DataBase Reference: 3-chloro-3-m-tolylpropan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-3-m-tolylpropan-1-ol(219745-19-4)
• EPA Substance Registry System: 3-chloro-3-m-tolylpropan-1-ol(219745-19-4)

Safety Data

• Hazardous Substances Data: 219745-19-4(Hazardous Substances Data)

Upstream product

• 51699-43-5 1-(3-methylphenyl)-1,3-propanediol 
• 100-80-1 3-methylstyrene 
• 628-51-3 diacetoxymethane 
• 200404-35-9 methyl 3-(m-tolyl)-3-oxopropanoate 

Relevant articles and documents

Boron trifluoride mediated prins reaction of methylene diacetate with styrenes. One-pot synthesis of 3-chloro-3-arylpropanols

A one-pot procedure was developed for the synthesis of 3-chloro-3- arylpropanols, which are important starting materials for the synthesis of biologically active benzanilide derivatives. Styrenes were reacted with methylene diacetate in the presence of boron trifluoride to give the corresponding 3-chloro-3-arylpropanols in 36-84% yield by the Prins reaction. A strongly electron-donating methoxy substituent at either the ortho or para position of the styrene did not give the expected 3-chloro-3-arylpropanols due to polymerization. Styrene with a strongly electron-withdrawing nitro substituent gave the corresponding 3-chloro-3-arylpropanol in very low yield. Under the same reaction conditions, substituted norbornene gave a tricyclic ether. A very easy procedure for the synthesis of methylene diacetate is also reported. Georg Thieme Verlag Stuttgart.

Synthesis of benzanilide derivatives as dual acting agents with α1- adrenoceptor antagonistic action and steroid 5-α reductase inhibitory activity

Synthesis of benzanilide derivatives which have dual α1-adrenoceptor antagonistic action and steroid 5α-reductase inhibitory activity and their structure-activity relationships is described.