21977-09-3

Basic information

• Product Name: MORPHOLIN-4-YL-ACETALDEHYDE MONOHYDRATE HYDROCHLORIDE
• Synonyms: MORPHOLIN-4-YL-ACETALDEHYDE MONOHYDRATE HYDROCHLORIDE;2-Morpholinoacetaldehyde;4-Morpholine acetaldehyde;Morpholin-4-ylacetaldehyde hydrochloride;4-Morpholineacetaldehyde HCl H2O
• CAS NO: 21977-09-3
• Molecular Formula: C₆H₁₁NO₂
• Molecular Weight: 129.16
• Mol File: 21977-09-3.mol

Chemical Properties

• Boiling Point: 308.4 °C at 760 mmHg
• Flash Point: 140.3 °C
• Appearance: /
• Density: 1.046 g/cm³
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 5.31±0.10(Predicted)
• CAS DataBase Reference: MORPHOLIN-4-YL-ACETALDEHYDE MONOHYDRATE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: MORPHOLIN-4-YL-ACETALDEHYDE MONOHYDRATE HYDROCHLORIDE(21977-09-3)
• EPA Substance Registry System: MORPHOLIN-4-YL-ACETALDEHYDE MONOHYDRATE HYDROCHLORIDE(21977-09-3)

Safety Data

• Statements: 43
• Safety Statements: 36/37
• HazardClass: IRRITANT
• Hazardous Substances Data: 21977-09-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
MORPHOLIN-4-YL-ACETALDEHYDE MONOHYDRATE HYDROCHLORIDE is used as an intermediate in the synthesis of various drugs and pharmaceuticals, playing a crucial role in the development of new medications.
Used in Organic Synthesis:
MORPHOLIN-4-YL-ACETALDEHYDE MONOHYDRATE HYDROCHLORIDE is employed as a reagent in organic synthesis, facilitating the creation of other chemical compounds for various applications.
Used in Chemical Production:
MORPHOLIN-4-YL-ACETALDEHYDE MONOHYDRATE HYDROCHLORIDE is utilized in the production of other chemical compounds, contributing to the chemical industry's diverse range of products.
It is essential to handle MORPHOLIN-4-YL-ACETALDEHYDE MONOHYDRATE HYDROCHLORIDE with proper safety measures and precautions to avoid potential hazards associated with its use and storage.

Upstream product

• 3616-59-9 4-(2,2-diethoxy-ethyl)-morpholine 
• 22633-57-4 4-(2,2-dimethoxyethyl)morpholine 

Relevant articles and documents

Design, synthesis, antiproliferative activity and docking studies of quinazoline derivatives bearing 2,3-dihydro-indole or 1,2,3,4-tetrahydroquinoline as potential EGFR inhibitors

Eight series of quinazoline derivatives bearing 2,3-dihydro-indole or 1,2,3,4-tetrahydroquinoline were designed, synthesized and evaluated for the IC50 values against three cancer cell lines (A549, MCF-7 and PC-3). Most of the forty nine target compounds showed excellent antiproliferative activity against one or several cancer cell lines. The compound 13a showed the best activity against A549, MCF-7 and PC-3 cancer cell lines, with the IC50 values of 1.09 ± 0.04 μM, 1.34 ± 0.13 μM and 1.23 ± 0.09 μM, respectively. Eight selected compounds were further selected to evaluated for the inhibitory activity against EGFR kinase. Three of them showed equal activity against EGFR kinase to positive control afatinib. AnnexinV-FITC, propidium iodide (PI) double staining and acridine orange single staining results indicated that the compound 13a could induce apoptosis of human lung cancer A549 cells.

MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN

There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of thrombin, which compounds include substituted pyrazolyl or substituted triazolyl. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing a disease or disorder, which disease or disorder is amenable to treatment or prevention by the inhibition of thrombin.

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Expeditious one-pot synthesis of C3-piperazinyl-substituted quinolines: Key precursors to potent c-Met inhibitors

An effective one-pot synthesis of quinolines bearing diverse C3-piperazinyl functions was developed by using a modified Friedlaender's protocol. The method not only enables the synthesis of our early reported c-Met inhibitor on a large scale, but also provides a way to generate novel multi-substituted quinolines for further structure-activity relationship (SAR) study.

MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN

There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of thrombin, which compounds include substituted pyrazolyl or substituted triazolyl. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing a disease or disorder, which disease or disorder is amenable to treatment or prevention by the inhibition of thrombin.

Identification of a novel class of selective Tpl2 kinase inhibitors: 4-Alkylamino-[1,7]naphthyridine-3-carbonitriles

We have previously reported the discovery and initial SAR of the [1,7]naphthyridine-3-carbonitriles and quinoline-3-carbonitriles as Tumor Progression Loci-2 (Tpl2) kinase inhibitors. In this paper, we report new SAR efforts which have led to the identifi