219773-66-7

Basic information

• Product Name: 4(1H)-Quinazolinone, 8-methoxy-2-(2-thienyl)- (9CI)
• Synonyms: 4(1H)-Quinazolinone, 8-methoxy-2-(2-thienyl)- (9CI)
• CAS NO: 219773-66-7
• Molecular Formula: C13H10N2O2S
• Molecular Weight: 0
• Mol File: 219773-66-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4(1H)-Quinazolinone, 8-methoxy-2-(2-thienyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Quinazolinone, 8-methoxy-2-(2-thienyl)- (9CI)(219773-66-7)
• EPA Substance Registry System: 4(1H)-Quinazolinone, 8-methoxy-2-(2-thienyl)- (9CI)(219773-66-7)

Safety Data

• Hazardous Substances Data: 219773-66-7(Hazardous Substances Data)

Upstream product

• 3177-80-8 2-amino-3-methoxybenzoic acid 
• 5271-67-0 2-Thiophenecarbonyl chloride 
• 219773-65-6 8-methoxy-2-(2'-thienyl)-4H-3,1-benzoxazin-4-one 

Relevant articles and documents

The design and synthesis of novel orally active inhibitors of AP-1 and NF-κB mediated transcriptional activation. SAR of in vitro and in vivo studies

We have developed novel orally active quinazoline analogues as inhibitors of AP-1 and NF-κB mediated transcriptional activation. Among the derivatives prepared, 1-[2-(2-thienyl)quinazolin-4-ylamino]-3-methyl-3- pyrroline-2,5-dione (10) showed significant activity in an adjuvant-induced arthritis rat model by reducing the swelling by 65% in the non-injected foot. The synthesis, structure-activity relationship, and in vivo activity are described.