219773-69-0

Basic information

• Product Name: 6,7-DIMETHOXY-2-(2-THIENYL)-4H-3,1-BENZOXAZIN-4-ONE
• Synonyms: 6,7-DIMETHOXY-2-(2-THIENYL)-4H-3,1-BENZOXAZIN-4-ONE
• CAS NO: 219773-69-0
• Molecular Formula: C₁₄H₁₁NO₄S
• Molecular Weight: 289.31
• Mol File: 219773-69-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6,7-DIMETHOXY-2-(2-THIENYL)-4H-3,1-BENZOXAZIN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-DIMETHOXY-2-(2-THIENYL)-4H-3,1-BENZOXAZIN-4-ONE(219773-69-0)
• EPA Substance Registry System: 6,7-DIMETHOXY-2-(2-THIENYL)-4H-3,1-BENZOXAZIN-4-ONE(219773-69-0)

Safety Data

• Hazardous Substances Data: 219773-69-0(Hazardous Substances Data)

Upstream product

• 332163-01-6 4,5-dimethoxy-2-[(thiophene-2-carbonyl)-amino]-benzoic acid 
• 5271-67-0 2-Thiophenecarbonyl chloride 
• 5653-40-7 2-Amino-4,5-dimethoxybenzoic acid 

Downstream Products

• 602333-27-7 6,7-dimethoxy-4-(2-hydrazinocarbonylphenylamino)-2-(2-thienyl)quinazoline 
• 602333-25-5 6,7-dimethoxy-4-(2-methoxy-carbonylphenylamino)-2-(2-thienyl)quinazoline 

Relevant articles and documents

The design and synthesis of novel orally active inhibitors of AP-1 and NF-κB mediated transcriptional activation. SAR of in vitro and in vivo studies

We have developed novel orally active quinazoline analogues as inhibitors of AP-1 and NF-κB mediated transcriptional activation. Among the derivatives prepared, 1-[2-(2-thienyl)quinazolin-4-ylamino]-3-methyl-3- pyrroline-2,5-dione (10) showed significant activity in an adjuvant-induced arthritis rat model by reducing the swelling by 65% in the non-injected foot. The synthesis, structure-activity relationship, and in vivo activity are described.