219783-74-1

Basic information

• Product Name: 2,3-dimethylbenzohydrazide(SALTDATA: FREE)
• Synonyms: 2,3-dimethylbenzohydrazide(SALTDATA: FREE)
• CAS NO: 219783-74-1
• Molecular Formula: C₉H₁₂N₂O
• Molecular Weight: 164.20438
• Mol File: 219783-74-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.098g/cm³
• Refractive Index: 1.561
• PKA: 12.80±0.10(Predicted)
• CAS DataBase Reference: 2,3-dimethylbenzohydrazide(SALTDATA: FREE)(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dimethylbenzohydrazide(SALTDATA: FREE)(219783-74-1)
• EPA Substance Registry System: 2,3-dimethylbenzohydrazide(SALTDATA: FREE)(219783-74-1)

Safety Data

• Hazardous Substances Data: 219783-74-1(Hazardous Substances Data)

Usage

General Description

2,3-dimethylbenzohydrazide, also known as SALTDATA: FREE, is a chemical compound that is commonly used as a stabilizer and inhibitor in a variety of industrial processes, including the production of polymers and coatings. It is a white to off-white crystalline powder with a melting point of 170-173°C, and is typically stored in a cool, dry place. 2,3-dimethylbenzohydrazide(SALTDATA: FREE) is a potent antioxidant and is known for its ability to effectively inhibit the degradation of polymers, thereby extending their shelf life and improving their performance. It is also used as a radical scavenger in certain chemical reactions, and as a photostabilizer in plastics and coatings. Due to its effectiveness and versatility, 2,3-dimethylbenzohydrazide is widely used in the manufacturing and processing of various industrial products.

InChI:InChI=1/C9H12N2O/c1-6-4-3-5-8(7(6)2)9(12)11-10/h3-5H,10H2,1-2H3,(H,11,12)

Upstream product

• 104175-24-8 ethyl 2,3-dimethylbenzoate 
• 603-79-2 2,3-dimethylbenzoic acid 

Relevant articles and documents

Synthesis, characterization and bioactivity studies of novel 1,3,4-oxadiazole small molecule that targets basic phospholipase A2 from Vipera russelli

Secretory phospholipase A2 (sPLA2) is a key enzyme participating in the inflammatory cascade followed by the action of cyclooxygenase-2 and lipoxygenases. Therefore, inhibitors of sPLA2 could be used as potent anti-inflammatory agents to treat the early phase of inflammation. In this study, we have prepared the fenoprofen and ibuprofen analogs containing 1,3,4-oxadiazole nucleus and tested against Vipera russelli venom's basic sPLA2 (VRV-PL-VIIIa). Among the tested ligands 5(a–t),2-(2-chlorophenyl)-5-(1-(4-phenoxyphenyl) ethyl)-1,3,4-oxadiazole (5m) inhibited the catalytic activity of VRV-PL-VIIIa with an IC50 value of 11.52?μM. Biophysical studies revealed that the 5m quenches the intrinsic fluorescence of VRV-PL-VIIIa, in a concentration dependent manner. Also, the compound 5m affected VRV-PL-VIIIa conformation, which was observed by circular dichroism spectra that recorded the prominent shift in the α-helix peak and the random coil formation of VRV-PL-VIIIa. Further, molecular docking analysis revealed that the compound 5m possess strong hydrophobic interactions at catalytic triad region of the VRV-PL-VIIIa. Evident to in vitro and in silico studies, 5m strongly inhibited the hemolysis of red blood cells. Our in vivo pharmacological studies revealed that the compound 5m inhibited the edematogenic activity of VRV-PL-VIIIa in?mouse foot pad. Additionally, the 5m inhibited VRV-PL-VIIIa-induced myotoxicity and lung hemorrhage in mice. Overall, our ADMET results depicted that 5m possess better druggable property. Thus, this study explored the new fenoprofen and ibuprofen analog 5m as the lead-structure that serves as an anti-inflammatory agent.