219784-11-9

Upstream product

• 67973-49-3 4,7-dihydroxy-8-methyl-2H-1-benzopyran-2-one 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 265325-07-3 5-Methyl-1H-pyrrole-2-carboxylic acid (2S,3R,4S,5S,6S)-3-hydroxy-5-methoxy-6-methyl-2-[8-methyl-2-oxo-4-(toluene-4-sulfonyloxy)-2H-chromen-7-yloxy]-tetrahydro-pyran-4-yl ester 

Relevant academic research and scientific papers

Tosylates in palladium-catalysed coupling reactions. Application to the synthesis of arylcoumarin inhibitors of gyrase B

The palladium-catalysed coupling reaction between tosylate derivatives and organostannanes has been investigated as a methodology for carbon-carbon bond formation. Aryl substituents have been successfully incorporated even in highly functionalised coumarin structures to afford new analogues of the antibiotic novobiocin. (C) 2000 Elsevier Science Ltd.