219788-08-6Relevant articles and documents
Spiro[2.2]pentane as a dissymmetric scaffold for conformationally constrained analogues of glutamic acid: Focus on racemic 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids
Pellicciari, Roberto,Marinozzi, Maura,Camaioni, Emidio,Nunez, Maria del Carmen,Costantino, Gabriele,Gasparini, Fabrizio,Giorgi, Gianluca,Macchiarulo, Antonio,Subramanian, Natarajan
, p. 5497 - 5507 (2002)
In search for novel conformationally constrained analogues of L-glutamic acid, a diastereodivergent synthesis of the four 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acid racemic pairs is reported along with their stereochemical assignment, conformational analysis, and preliminary biological evaluation as potential glutamate (ionotropic and metabotropic) ligands.