2198-93-8Relevant articles and documents
Trichodermates A-F, New Cytotoxic Trichothecenes from the Plant Pathogenic Fungus Trichoderma sp.
Li, Jiaying,Ren, Jinwei,Bao, Li,Jin, Tao,Wang, Wenzhao,Pei, Yunfei,Liu, Xingzhong,Li, Erwei
, p. 63 - 69 (2016)
Trichodermates A - F (1-6, resp.), six new trichothecene polyunsaturated octadioic acid esters, and (-)-harzianum B (7) were isolated from the fermentation extract of Trichoderma sp., a plant pathogenic fungus isolated from stem rot of an unidentified tree in Thailand. The structures of 1-7 were elucidated by NMR experiments. The absolute configuration at C(12) in 3 was assigned by in situ dimolybdenum circular dichroism method, whereas that in 7 was deduced after hydrolysis of 7 to 8 via modified Mosher's method. Compounds 1 and 2 showed modest cytotoxic activities against the K562 (human myelogenous leukemia) cell line with IC50 values of 12.12 and 13.08 μM, respectively.
Synthesis of trichodermin derivatives and their antimicrobial and cytotoxic activities
Barúa, Javier E.,De la Cruz, Mercedes,De Pedro, Nuria,Cautain, Bastien,Hermosa, Rosa,Cardoza, Rosa E.,Gutiérrez, Santiago,Monte, Enrique,Vicente, Francisca,Collado, Isidro G.
, (2019)
Trichothecene mycotoxins are recognized as highly bioactive compounds that can be used in the design of new useful bioactive molecules. In Trichoderma brevicompactum, the first specific step in trichothecene biosynthesis is carried out by a terpene cyclas
Synthesis and antifungal activity of trichodermin derivatives
Cheng, Jing Li,Zhou, Yong,Zhao, Jin Hao,Zhang, Chulong,Lin, Fu Cheng
scheme or table, p. 1037 - 1040 (2011/10/05)
A series of derivatives were synthesized from trichodermin (1) which was an antifungal metabolite produced by Trichoderma taxi sp. nov. Their structures were confirmed by 1H NMR, MS spectrum. Their antifungal activities were evaluated in vitro. The preliminary structure activity relationships (SAR) results indicated that the double bond, epoxide moiety and ester group were main pharmacophore elements, the stereochemistry of C4 position played a key role as well, and the compounds 1e-1g displayed stronger antifungal activity against Magnaporthe grisea than 1.