219801-01-1Relevant academic research and scientific papers
Base-Mediated Syntheses of Di- and Trisubstituted Imidazoles from Amidine Hydrochlorides and Bromoacetylenes
Chen, Xiao Yun,Englert, Ulli,Bolm, Carsten
, p. 13221 - 13224 (2015)
A new transition metal-free method for the preparation of substituted imidazoles from easy-to-handle amidine hydrochlorides and bromoacetylenes has been developed. The reactions proceed in air and use inexpensive K2CO3 as base. Additions of 2,2′-bipyridine and water have beneficial effects on the product yields. Various di- and trisubstituted imidazoles have been prepared in good yields (up to 88%). A new transition metal-free method for the preparation of di- and trisubstituted imidazoles in good yields from easy-to-handle amidine hydrochlorides and bromoacetylenes has been developed. The reactions proceed in air and use inexpensive K2CO3 as base. Additions of 2,2′-bipyridine and water have beneficial effects on the product yields.
Identification and characterization of diarylimidazoles as hybrid inhibitors of butyrylcholinesterase and amyloid beta fibril formation
Karlsson, Daniela,Fallarero, Adyary,Brunhofer, Gerda,Guzik, Przemyslaw,Prinz, Michaela,Holzgrabe, Ulrike,Erker, Thomas,Vuorela, Pia
scheme or table, p. 169 - 183 (2012/04/23)
In this contribution, a chemical collection of aromatic compounds was screened for inhibition on butyrylcholinesterase (BChE)'s hydrolase activity using Ellman's reaction. A set of diarylimidazoles was identified as highly selective inhibitors of BChE hyd
