219810-73-8

Upstream product

• 10467-10-4 ethylmagnesium iodide 
• 28017-78-9 3-Aethyl-5,5-dimethyl-2-cyclohexen-1-on 

Downstream Products

• 219810-88-5 3,3-diethyl-1,5,5-trimethyl-cyclohexanol 
• 524943-18-8 1-Allyl-3,3-diethyl-5,5-dimethylcyclohexanol 
• 219811-17-3 1-azido-3,3-diethyl-1,5,5-trimethyl-cyclohexane 

Relevant academic research and scientific papers

Synthesis and structure-affinity relationships of 1,3,5-alkylsubstituted cyclohexylamines binding at NMDA receptor PCP site

A series of 1,3,5-alkylsubstituted cyclohexylamines 2 were synthesized as ligands for the N-methyl-D-aspartate (NMDA) receptor phencyclidine (PCP) binding site. Pure diastereomers with defined configuration of amino group 2- ax and 2-eq were obtained. The optimal size of 1,3,5-substituents was determined for cyclohexylamines 2 with an equatorial amino group in the lowest energy conformation using Hansch analysis. According to the data, the lipophilic part of cyclohexylamines 2 does not discriminate between hydrophobic regions of the PCP binding site but rather recognizes this site as a whole lipophilic pocket. (C) 2000 Editions scientifiques et medicales Elsevier SAS.