219821-18-8

Basic information

• Product Name: (S)-4-BENZYL-1,3-THIAZOLIDINE-2-ONE
• Synonyms: 2-Thiazolidinone, 4-(phenylmethyl)-, (4S)-;(4S)-4-benzyl-1,3-thiazolidin-2-one
• CAS NO: 219821-18-8
• Molecular Formula: C₁₀H₁₁NOS
• Molecular Weight: 193.27
• Mol File: 219821-18-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.215g/cm³
• Refractive Index: 1.603
• CAS DataBase Reference: (S)-4-BENZYL-1,3-THIAZOLIDINE-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-BENZYL-1,3-THIAZOLIDINE-2-ONE(219821-18-8)
• EPA Substance Registry System: (S)-4-BENZYL-1,3-THIAZOLIDINE-2-ONE(219821-18-8)

Safety Data

• Hazardous Substances Data: 219821-18-8(Hazardous Substances Data)

Usage

General Description

(S)-4-Benzyl-1,3-thiazolidine-2-one is a chemical compound with a thiazolidine ring and a benzyl group. It is commonly used as a building block in the synthesis of pharmaceuticals and organic compounds. This thiazolidine derivative has shown potential bioactivity in various studies, including its anti-inflammatory and antiviral properties. Its structure and functional groups make it a versatile intermediate for the preparation of diverse molecules with potential therapeutic applications. Additionally, (S)-4-Benzyl-1,3-thiazolidine-2-one has been studied for its potential as an anti-cancer agent, highlighting its importance in medicinal chemistry and drug discovery research.

InChI:InChI=1/C10H11NOS/c12-10-11-9(7-13-10)6-8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H,11,12)/t9-/m0/s1

Upstream product

• 171877-39-7 (S)-4-benzylthiazolidin-2-thione 

Downstream Products

• 1008742-67-3 3-{4-[(4S)-4-benzyl-2-oxo-1,3-thiazolidin-3-yl]-4-oxobutyl}-1,2,3-benzotriazin-4(3H)-one 

Relevant articles and documents

Desulfurization-oxygenation of chiral 1,3-thiazolidine-2-thiones and 1,3-oxazolidine-2-thiones using propylene oxide and microwave irradiation

An efficient method for the desulfurization-oxygenation of 1,3-thiazolidine-2-thiones and 1,3-oxazolidine-2-thiones using propylene oxide and employing microwave irradiation is described. This strategy of oxygenation of the thiocarbonyl group provides an attractive methodology to prepare chiral 1,3-thiazolidin-2-ones and 1,3-oxazolidin-2-ones from the corresponding precursors in good yields. Copyright

MATRIX METALLOPROTEINASE INHIBITORS

The present invention relates to β-hydroxy and amino substituted carboxylic acids, which act as matrix metalloprotease inhibitors, particularly diastereomerically pure β-hydroxy carboxylic acids, corresponding processes for the synthesis of and pharmaceutical compositions containing the compounds of the present invention. Compounds of the present invention are useful in the treatment of various inflammatory, autoimmune and allergic diseases, such as methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, wound healing disorders, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by the over-expression and over- activation of a matrix metalloproteinase using the compounds.