219828-05-4Relevant academic research and scientific papers
Cp2ZrCl2- Et3Al reagent system in the homo-coupling of trimethylsilyl-substituted alkynes
Amirova, Aliya K.,Dzhemilev, Usein M.,Kadikova, Rita N.,Mozgovoj, Oleg S.,Ramazanov, Ilfir R.
, p. 39518 - 39522 (2021/12/27)
The reaction of trimethylsilyl-substituted alkynes with 0.5 equivalents of Cp2ZrCl2and 1 equivalent of Et3Al in toluene at room temperature for 18 hours gives, after hydrolysis/deuterolysis or iodination, functionalized products of the homo-coupling of silyl-substituted alkynes in good yield. Trimethylsilyl-substituted α,ω-diynes react with the Cp2ZrCl2- Et3Al reagent system to give (1Z,2Z)-1,2-bis(iodo(trimethylsilyl)methylene)cycloalkanes after iodinolysis.
HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF
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Page/Page column 72, (2013/08/28)
Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
