219838-93-4

Basic information

• Product Name: Pyridine, 2,3,5,6-tetrafluoro-4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl] -
• CAS NO: 219838-93-4
• Molecular Formula: C19H9F5N4
• Molecular Weight: 388.299
• Mol File: 219838-93-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Pyridine, 2,3,5,6-tetrafluoro-4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl] -(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2,3,5,6-tetrafluoro-4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl] -(219838-93-4)
• EPA Substance Registry System: Pyridine, 2,3,5,6-tetrafluoro-4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl] -(219838-93-4)

Safety Data

• Hazardous Substances Data: 219838-93-4(Hazardous Substances Data)

Upstream product

• 700-16-3 Pentafluoropyridine 
• 219839-25-5 4-(4-fluorophenyl)-5-(pyridin-4-yl)-1-(1,1-diethoxymethyl)-imidazole 

Relevant articles and documents

SAR of 2,6-diamino-3,5-difluoropyridinyl substituted heterocycles as novel p38MAP kinase inhibitors.

2,6-Diamino-3,5-difluoropyridinyl substituted pyridinylimidazoles, -pyrroles, -oxazoles, -thiazoles and -triazoles have been identified as novel p38alpha inhibitors. Pyridinylimidazole 11 potently inhibited LPS-induced TNFalpha in mice, showed good efficacy in the established rat adjuvant (ED(50): 10 mg/kg po b.i.d.) and collagen induced arthritis (ED(50): 5 mg/kg po b.i.d.) with disease modifying properties based on histological analysis of the joints.