219839-06-2

Upstream product

• 1445-73-4 1-Methyl-4-piperidone 
• 219839-25-5 4-(4-fluorophenyl)-5-(pyridin-4-yl)-1-(1,1-diethoxymethyl)-imidazole 
• 181630-93-3 4-(4-Fluorophenyl)-5-(pyridin-4-yl)-1H-imidazole 
• 6576-05-2 1-(4-fluorophenyl)-2-(4-pyridyl)ethanone 

Relevant academic research and scientific papers

SAR of 4-hydroxypiperidine and hydroxyalkyl substituted heterocycles as novel p38 Map kinase inhibitors

The 4-hydroxypiperidine substituent was found to confer high p38 selectivity devoid of COX-1 affinity, when attached to a series of pyridinyl substituted heterocycles. Pyridinyloxazole 11 showed a promising in vivo profile with bioavailability of 64% and