21985-06-8 Usage
Uses
Used in Organic Synthesis:
1-(5-bromothiophen-2-yl)-3-phenylprop-2-yn-1-one is used as a building block in organic synthesis for its unique structure and reactivity, allowing for the creation of a variety of complex molecules.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-(5-bromothiophen-2-yl)-3-phenylprop-2-yn-1-one is used as a key intermediate in the development of new pharmaceuticals, thanks to its potential for chemical modifications and its interesting properties.
Used as a Pharmaceutical Intermediate:
1-(5-bromothiophen-2-yl)-3-phenylprop-2-yn-1-one serves as a valuable pharmaceutical intermediate due to its structural features and the possibility of further functionalization, which can lead to the synthesis of novel therapeutic agents.
Used in Chemical Reactions:
1-(5-bromothiophen-2-yl)-3-phenylprop-2-yn-1-one is utilized in various chemical reactions, taking advantage of its triple bond and carbonyl group, as well as the reactivity of the bromine and thiophene elements within its structure.
Used in Biological Interactions:
The unique properties of 1-(5-bromothiophen-2-yl)-3-phenylprop-2-yn-1-one make it a candidate for exploring its potential in biological interactions, which could lead to applications in the development of new drugs or biological probes.
Check Digit Verification of cas no
The CAS Registry Mumber 21985-06-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,9,8 and 5 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 21985-06:
(7*2)+(6*1)+(5*9)+(4*8)+(3*5)+(2*0)+(1*6)=118
118 % 10 = 8
So 21985-06-8 is a valid CAS Registry Number.
21985-06-8Relevant academic research and scientific papers
Stitching Ynones with Nitromethanes: Domino Synthesis of Functionally Enriched Benzofurans and Benzothiophenes
Mehta, Goverdhan,Nerella, Sharanya,Pabbaraja, Srihari,Singh, Shweta
, p. 12093 - 12106 (2021/09/13)
A convenient one-pot benzannulation of regioisomeric 2- or 3-substituted furan and thiophene ynones with a range of nitromethanes has been discovered to directly access densely and diversely functionalized benzofurans and benzothiophenes. In this protocol, the nitro group in nitromethanes functions as recursive carbanion activator to setup tandem Michael addition-6π-electrocyclization, and its eventual sacrificial elimination facilitates aromatization and overall benzannulation. This benzannulation was also explored with furan/thiophene based o-halo ynones wherein a Michael addition-SNAr process operates and nitromethanes leave their imprint to deliver nitro substituted benzo-furans and -thiophenes.
