219858-73-8Relevant academic research and scientific papers
A new transformation of 2H-pyran-2-one ring: First synthesis of pyridazino[4,3-c]azepines and their oxidation with Thallium(III) nitrate or copper(II) acetate
Kafka, Stanislav,Treb?e, Polonca,Polanc, Slovenko,Ko?evar, Marijan
, p. 254 - 256 (2000)
A novel reaction starting from pyrano[3,2-c]azepines 1 and hydrazine hydrate was used for the preparation of the first derivatives of pyridazino[4,3-c]azepines 2. They were further oxidised by thallium(III) nitrate trihydrate (TIN) or copper(II) acetate hydrate (CuDA) to give aromatised fused pyridazine derivatives 5 also containing an ester function formed from the carbohydrazide moiety.
