219862-76-7

Upstream product

• 177839-89-3 (R)-tert-butyl 4-hydroxy-1-phenylbutan-2-ylcarbamate 
• 115313-20-7 methyl 3-(R)-[N-(tert-butoxycarbonyl)amino]-4-phenylbutanoate 

Downstream Products

• 372186-53-3 2-(3-tert-butoxycarbonylamino-4-phenyl-butyl)-malonic acid dimethyl ester 
• 372186-54-4 2-(3-azido-propyl)-2-(3-tert-butoxycarbonylamino-4-phenyl-butyl)-malonic acid dimethyl ester 
• 372186-55-5 2-(3-azido-propyl)-5-tert-butoxycarbonylamino-6-phenyl-hexanoic acid 
• 372186-59-9 (3S,6S)-3-(3-Azido-propyl)-6-benzyl-2-oxo-piperidine-1-carboxylic acid tert-butyl ester 
• 372186-58-8 (3R,6S)-3-(3-Azido-propyl)-6-benzyl-2-oxo-piperidine-1-carboxylic acid tert-butyl ester 
• 372186-57-7 (3S,6S)-3-(3-Azido-propyl)-6-benzyl-piperidin-2-one 
• 372186-56-6 (3R,6S)-3-(3-Azido-propyl)-6-benzyl-piperidin-2-one 

Relevant academic research and scientific papers

Preparation of 'carba' dipeptides bearing a basic side-chain at the C-terminus: Synthesis of enantiopure Boc-D-Phe-Ψ[CH2CH2]-L-Arg(NO2)-OH and Boc-D-Phe-Ψ[CH2CH2]-D-Arg(NO2)OH

A new approach to synthesize 'carba' Ψ[CH2CH2] dipeptides, e.g. Boc-D-Phe-Ψ[CH2CH2]-L-Arg(NO2)-OH and Boc-D-Phe-Ψ[CH2CH2]-D-Arg(NO2)-OH, is described.

Inhibitors of farnesyl protein transferase

Disclosed are quinoline and benzazepine derivatives that inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogenic protein Ras. Thus, the compounds are useful as anti-cancer agents. The compounds are also useful in the treatment of diseases other than cancer.