219869-94-0Relevant academic research and scientific papers
Synthesis of COX-2 and FAAH inhibitors
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, (2008/06/13)
Methods for preparing indoles that are useful COX-2 inhibitors and intermediates useful in such methods are described.
Synthesis of 4,6-difluoro-5-hydroxy-(α-methyl)tryptamine and 4,6-difluoro-5-hydroxy-(β-methyl)tryptamine as potential selective monoamine oxidase B inhibitors
Chen, Hauh-Jyun Candy,Applewhite, Terrence,Jayachandran,Kirk, Kenneth L.
, p. 41 - 44 (2007/10/03)
Condensation of 4-nitro-1-pentanal and 4-nitropentanal 3-methylbutanal with 3,5-difluoro-4-methoxyphenylhydrazine afforded 4,6-difluoro-5-methoxy-3-(2′-nitro)propylindole 4a and 4,6-difluoro-5-methoxy-3-(1′-methyl-2′-nitro)ethylindole 4b, respectively, in one step. Reduction of the nitro group with lithium aluminum hydride followed by removal of the methyl ether with boron tribromide produced the title compounds. They were inactive as MAO B inhibitors.
