219897-66-2Relevant academic research and scientific papers
Simple and convenient methods for synthesis, resolution and application of aminonaphthols
Periasamy, Mariappan,Anwar, Shaik,Reddy, Meda Narsi
experimental part, p. 1261 - 1273 (2010/02/28)
Racemic aminonaphthols are obtained in 70-95% yield by simple and straightforward condensation of benzaldehyde, 2naphlhol and 1° or 2° amines in ethanol solvent under refluxing conditions. The racemic aminonaphthols 1-(αaminobcnzyl)-2-naphthol and 1-(α-pyrrolidinylbenzyl)-2-naphthol have been resolved using L -(+)-tartaric acid. The racemic l-(a-/V- butylaminobenzyl)-2-naphthol and l-(a-piperidylbenzyl)-2-naphthol have been resolved using fl-(+)-BINOL and boric acid. The racemic (2-methoxynaphth-1-yl) benzylamine is resolved using dibenzoyl-L-(-)-tartaric acid. The readiliy accessible chiral aminonaphthols are useful for resolution of important moieties like racemic BINOL, ibuprofen and mandclic acid.
The Betti base: Absolute configuration and routes to a family of related chiral nonracemic bases
Cardellicchio, Cosimo,Ciccarella, Giuseppe,Naso, Francesco,Schingaro, Emanuela,Scordari, Fernando
, p. 3667 - 3675 (2007/10/03)
A detailed protocol for the resolution of the Betti base [i.e. 1-(α- aminobenzyl)-2-naphthol] was investigated and the absolute configuration of the two isomers was established by means of an X-ray diffractometric study. A series of optically active deriv
