219904-77-5Relevant academic research and scientific papers
Synthesis of 2,4-diamino-5,6,7,8,9,10-hexahydro-5,9-methanopyrimido [4,5-b]azocine
Taylor, Edward C.,Dowling, James E.,Bhatia, Beena
, p. 441 - 446 (1999)
We have initiated a program aimed at the synthesis of derivatives of 2,4-diamino-5,6,7,8,9,10-hexahydro-5,9-methanopyrimido[4,5-b]azocine (3) as potential selective inhibitors of Pneumocystis carinii DHFR. The present paper describes a simple synthesis of 3 from 2,4,6-triaminopyrimidine and 2- cyclohexen-1-one as well as methodology for the introduction of a variety of substituents at bridgehead position C-9.
